This study was carried out to investigate accumulation of metallothionein(MT) in rat liver and kidney by cadmium administration. After male rats of Sprague-Dawley strain weighing 60±5g were fed basal diet ad libitum for 4 weeks, two types of
experiments were performed, In the first set of experiment, rats were divided into five groups. Control groups was fed basal diet without injection of cadmium. Dose groups of A, B, C and D were i.p. injected 0.625, 1.26, 2.5, 5mg Cd/kg of body
wt,
oncc
a day for two days. In the second set of experiment, rats were also divided into five groups,. Control group was fed basal diet without injection of cadmium. Number group of I, II, III and IV were i.p. injected 1, 2, 3, and 4 times every 24hrs,
respectively and injection doses were 2.5mg Cd/Kg of body wt. In a day. In the first of experiment, hemoglobin contents in C, D groups were lower than control group. MT concentrations in liver and kidney were increased with increasing Cd
injection
doses
to 2.5mg Cd/kg of body wt, Liver-SH group values in C, D groups were higher than control group, Hematocrit values did not differ among groups. In the second of experiment, hemoglobin contents and hematocrit values were decreased, MT
concentration
in
liver and kidney were progressively increased with increasing number of Cd injection, In both sets of experiments, liver MT concentrations were higher than kidney.
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